Fig. 1

A scheme illustrating the hierarchical structure of interphase chromatin. Chromosome territories (at the top of the picture) are partitioned into A- and B-compartments (a) formed by long-range spatial interactions between distant genome loci and containing active and repressed genome regions, respectively. At a sub-megabase level, chromatin is folded into topologically-associating domains, TADs (b), commonly interpreted as self-interacting globular structures those positions are largely conserved across cell types. The internal structure of TADs is represented by arrays of so-called loop domains formed by spatial contacts between CTCF/cohesin-binding sites (c). Color intensity on illustrative Hi-C maps (on the left side of each panel) reflects average interaction frequency between corresponding genomic bins