Fig. 2

Protective effects of obacunone (OB) against lipopolysaccharide (LPS)-induced acute lung injury (ALI) in mice. A Representative images of mouse lung tissues. Lung tissues (n = 6) from each experimental group were processed for histological evaluation following the LPS challenge. B Representative hematoxylin and eosin (HE) staining images of the lung tissues. C Representative terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) fluorescence images of the lung tissues. D Lung wet weight/dry (W/D) weight ratio. E–G Total cell and neutrophil count and protein concentration in bronchoalveolar lavage fluid (BALF). H–J IL-1β, IL-6, and TNF-α concentrations in the BALF. K, L KL-6 and CRP in plasma. M, N LYM (%) and NEU (%) in EDTA anticoagulation blood. Similar results were obtained from three independent experiments. All data are presented as mean ± SEM (n = 6 for each group). ^#/*P < 0.05, ^##/**P < 0.01, ^###/***P < 0.001, ^# versus control group; * versus LPS group