Lectins and lectibodies: potential promising antiviral agents

Nabi-Afjadi, Mohsen; Heydari, Morteza; Zalpoor, Hamidreza; Arman, Ibrahim; Sadoughi, Arezoo; Sahami, Parisa; Aghazadeh, Safiyeh

doi:10.1186/s11658-022-00338-4

Cellular & Molecular Biology Letters

Table 1 General features of antiviral lectins

From: Lectins and lectibodies: potential promising antiviral agents

Source	Kingdom	Lectin	Mw (× 1000) per monomer	Residue per monomer	Oligomeric status	CRDs	Structure class	Glycan specificity	Refs.
Actinomycete Longisporum albida	Bacteria	AH	12.5	114	Monomeric	3	β-Trefoil	α(1,2)-Mannose	[153,154,155,156]
Cyanobacterium Nostoc ellipsosporum	Bacteria	CV-N	11	101	Monomeric–dimeric	2	Cyanovirin-like	α(1,2)-Mannose	[41, 46]
Cyanobacterium Microcystis aeruginosa	Bacteria	MVN	14.2	108	Monomeric	1	Cyanovirin-like	α(1,2)-Mannose	[47,48,49]
Cyanobacterium Microcystis viridis	Bacteria	MVL	13	113	Homodimeric	4	Cyanovirin-like	Man3GlcNAc2, Man6GlcNAc2	[176, 177]
Cyanobacterium Scytonema varium	Bacteria	SVN	9.7	95	Monomeric	2	Cyanovirin-like	Man-α(1–2) Man-α(1–6) Man-α(1–6) Man	[10,11,12]
Cyanobacterium Oscillatoria agardhii	Bacteria	OAA	13.9	133	Monomeric	2	OAAH	Man-α(1–6)Man, Man-8/9	[52,53,54,55]
Actinomadura hibisca	Bacteria	PRM-A	8.5	–	Dimeric	4	–	α(1,2)-Mannose	[58,59,60,61]
Griffithsia sp.	Protista	GRFT	12.7	121	Homodimeric	6	β-Prism type 1	α(1,2), α(1,6), mannotetrose, man5-9	[103,104,105,106,107, 178]
Boodlea coacta	Protista	BCA	13.8	118	Monomeric	3	β-Prism type 1	α(1,2)-Mannose	[64]
Musa acuminata cultivars	Plantae	BanLec	15	141	Homotetrameric	8	β-Prism type 1	α-1,6 mannotetrose α-D manno/glycosyl, α-1,3 mannosyl1/β-1,3-glycosyl	[166,167,168,169,170]
Galanthus nivalis	Plantae	GNA	12.5	157	Homotetrameric	12	β-Prism type 2	α1-3 or α1-6 linked mannose	[125,126,127,128,129]
Hippeastrum hybrid	Plantae	HHA	12.5	157	Homotetrameric	12	β-Prism type 2	α1-3 or α1-6 linked mannose	[125,126,127,128,129]
Polygonatum cyrtonema Hau	Plantae	PCL	12	110	Dimeric	6	β-Prism type 2	α(1,3)-Dimannoside	[179,180,181]
Urtica dioicia	Plantae	UDA	8.7	89	Monomeric	2	Hevein-like	(N-acetyl-d-glucosamine)₃	[182,183,184]
Nicotiana tabacum var. Samsun NN	Plantae	NICTABA	19	165	Homodimeric	2	Unk	GlcNAc2Man3	[185,186,187]
Phaseolus vulgaris	Plantae	PHA	~ 30	–	Homo/heterotetrameric	4	β-Sandwich	Galβ-(1–4)GlcNAcβ-(1–2)Man	[135,136,137,138]
Lens culinaris	Plantae	LCA	~ 25	–	Homodimeric	2	β-Sandwich	FucMan3GlcNAc2, Man5-9, GlcNAc	[140,141,142,143,144]
Serpula vermicularis	Animalia	SVL	~ 12.7	–	Homotetrameric	–	Unk	N-acetyl-d-glucosamine	[13]
Crenomytilus grayanus	Animalia	CGL	18	150	Homodimeric	6	β-Trefoil	GalNAc/Gal	[65,66,67,68,69,70,71,72,73]

AH actinohivin, CV-N cyanovirin, MVN microvirin, MVL Microcystis viridis lectin, SVN scytovirin, OAA Oscillatoria agardhii agglutinin, PRM-A pradimicin A, GRFT griffithsin, BCA Boodlea coacta agglutinin, BanLec banana lectin, GNA Galanthus nivalis agglutinin, HHA Hippeastrum hybrid agglutinin, PCL Polygonatum cyrtonema lectin, UDA Urtica dioicia agglutinin, NICTABA Nicotiana tabacum agglutinin, PHA phytohemagglutinin, LCA Lens culinaris agglutinin, SVL Serpula vermicularis lectin, CGL Crenomytilus grayanus lectin

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ISSN: 1689-1392

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