Table 2 Role of miRNAs in pathogenesis by either increasing or decreasing cell proliferation [46]
From: The role of epigenetic modifications in drug resistance and treatment of breast cancer
Main function | miRNAs | Function of miRNAs |
|---|---|---|
Increasing cell proliferation | miR-1207-5p | Regulating STAT2 expression Inactivating cell-cycle-dependent kinase inhibitors including CDKN1A and CDKN1B |
miR-492 | Upregulating cyclin D1 and c-MYC Repressing the expression of SOX7, deemed as a transcription factor | |
miR-135b | Negatively regulating LATS2 tumor suppressor kinase and the Hippo pathway | |
Decreasing cell proliferation | miR-143 | Suppressing the expression of extracellular signal-regulated kinase ERK5 Suppression of mitogen-activated protein kinase MAP3K7 and cyclin D1 |
miR-455 | A double-knockdown impact of Cdc2-related protein kinase CDK14 Cyclin D1 expression Promoting expression of tumor suppressor p21 | |
miR-424 | Binding to its selective target, cyclin-dependent kinase CDK1 in G2-M cell phase The expression of the Yes-associated protein YAP by both the Hippo pathway and p-ERK1/2 of the ERK pathway | |
miR-543 | Direct regulating of ERK/MAPK pathway | |
miR-26a-5p | Reducing the expression of cell cycle regulators cyclin D1, CDK4, and CDK6 Increasing the expression of tumor suppressor proteins such as p21, p27, and p53 |