Table 1 Studies that investigated the melatonin-induced modification of DNA methylation against cancer
From: Melatonin and cancer suppression: insights into its effects on DNA methylation
Cancer Type | Cell line(s) | Study Model and Dosage(s) | Affected Gene(s) | Ref. |
|---|---|---|---|---|
Malignant glioma | A172, U87, U373, and BTSCs | In vitro, 0–1mM for 24 and 48 h | ABCG2/BCRP | [77] |
Colorectal cancer | Caco-2 | In vitro, 1-100 nmol/L | NF-κB, IL‐6, -8, COX‐2, and NO | [79] |
Breast cancer | 4T1 | In vivo (n = 12/group), 33 mg/L in drinking water | Global DNA methylation | [83] |
Breast cancer | MCF-7 | In vitro, 1 and 100 nM | EGR3, POU4F2/Brn-3b, and GPC3 | [84] |
Breast cancer | 4T1 | In vivo, 10 mg/L in drinking water | Global DNA methylation | [85] |
Breast cancer | MCF-7 | In vitro 10 nM for 24 h, and In vivo (n = 3/group) 0.1 mg/mL in drinking water | STAT3, IL-6, and ARH1 | [90] |
Breast cancer | 4T1 | In vivo (n = 10/group) 1.9 mg/kg/d | Global DNA methylation | [93] |