Fig. 1

LARRPM was downregulated and associated with prognosis in LUAD. a Correlation between LARRPM expression and overall survival analyzed using the TCGA LUAD dataset. HR = 0.4167, P = 0.0006, log-rank test. n = 248, median LARRPM expression level was used as the cut-off. b LARRPM expression levels in T1-and T2-stage LUAD tissues analyzed using the TCGA dataset. P = 0.0136, Mann–Whitney test. c LARRPM expression levels in TNM stages-I and -I LUAD tissues analyzed using the TCGA dataset. P = 0.0278, Mann–Whitney test. d Correlation between LARRPM expression and overall survival analyzed using our LUAD cohort data. HR = 0.4743, P = 0.0244, log-rank test. n = 70, median LARRPM expression level was used as the cut-off. e LARRPM expression in 70 pairs of LUAD tissues and matched adjacent lung tissues was detected by qRT-PCR. P < 0.0001, Wilcoxon matched-pairs signed rank test. f LARRPM expression in 16HBE cells and LUAD cells A549, H1299, H1975, and HCC827 was detected by qRT-PCR. Results are shown as mean ± standard deviation (SD) based on three independent experiments. Asterisks indicate a significant difference at ***P < 0.001, ****P < 0.0001, by one-way analysis of variance (ANOVA) followed by Dunnett's multiple comparisons test. 16HBE Human bronchial epithelial cell line, A549, H1299, H1975, HCC827 human LUAD cell lines, HR hazard ratio, LARRPM a LUAD-related long non-coding RNA, LUAD lung adenocarcinoma, qRT-PCR reverse-transcription quantitative PCR, T1, T2 TNM stages T1, T2, TCGA The Cancer Genome Atlas