Fig. 2

Expression of COX19 and COX4I2 in relation to clinical features of CRC. a, b COX19 (a) and COX4I2 (B) mRNA levels in various human tumor and normal tissues, from the TIMER database (n = 480). c, d Dataset GSE37182 (n = 172) from the GEO showing COX19 (c) and COX4I2 (d) mRNA levels in CRC. Wilcoxon test was performed. e, f Dataset GSE10950 (n = 48) from GEO showing COX19 (e) and COX4I2 (f) mRNA levels in CRC. Wilcoxon test was performed. g Expression of COX19 and COX4I2 in CRC, from TCGA-COAD (n = 41). h Association of COX19 and COX4I2 mRNA levels with the T (Tumor) (n = 477), N (Node) (n = 478), and M (Metastasis) (n = 411) stages. i, j Correlation of COX19 (i) and COX4I2 (j) levels with CRC patient OS and DFS, from the the GEPIA database (n = 269). k, l The overall survival, progression-free interval, and disease-specific survival from the TCGA-COAD data in relation to COX19 (k) and COX4I2 (l) expression (n = 477). Asterisks indicate significant difference at *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001; ns, not significant. GEO Gene Expression Omnibus, mRNA messenger; for other Abbreviations, see Abbreviation list