Fig. 6
From: Exosomal DNAJB11 promotes the development of pancreatic cancer by modulating the EGFR/MAPK pathway
DNAJB11 inhibited ER stress activity by the PERK-ATF4 pathway and induced the EGFR/MAPK pathway. A. The UPR pathway was upregulated in the WT group by GSEA. B Functional network integration was performed by GeneMANIA. C The protein levels of DNAJB11, HSPA5, ATF6, IRE1, XBP1, PERK, ATF4, and GAPDH were measured by western blot analysis. D EGFR was inhibited in the DNAJB11-knockdown group by GSEA. E Correlation analysis of DNAJB11 and EGFR by UALCAN. F After incubation with exosomes, the protein levels of DNAJB11, EGFR, p-EGFR, Raf-1, MEK, p-MEK, ERK1/2, p-ERK1/2, c-MYC, and GAPDH were measured by western blot analysis