Fig. 6

Targeting UCK2 facilitated NK cell surveillance. A Genes related to innate immune system were enriched in signalling pathway. B GSEA revealed the relationship between signalling pathways and UCK2. C Heatmap showed the expression of genes involved in SASP in the indicated cell lines. D WB examined the protein expression of pNFKB, NFKB and ICAM1 in the indicated cell lines. E IF detected the expression of ICAM1 in the indicated cell lines. F CCK8 assays was used to determine the proliferation of the indicated cell lines; the cells were incubated with NFKB signalling pathway inhibitor BAY11-7082, 7.5 µM. G Correlation between UCK2 and different types of NK cell. H Kaplan–Meier curve suggested the combined effect of UCK2 and activated NK cell on the prognosis of HCC. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001