Fig. 3

A–D ATC-specific copy number variations and annotated biological functions. A CNV gain and loss events in ATC (8305C) and both PTC (BCPAP and TPC-1) cell lines; B intersection plot of multiple subgroups of CNV statuses in ATC and both PTC cells; C, D significantly enriched Gene Ontology (biological functions) in genes associated with ATC-specific CNVs gain and loss events. E–J CNV breakpoints associated with TAD boundaries. The distribution plots of the distance between all CNV breakpoints (red line) and random sites (green line) to their nearest TAD boundaries in E ATC (8305C), and F PTC (BCPAP), and G PTC (TPC-1) cells; distributions of distances (kb) from various CNV events to the nearest TAD boundaries in H ATC (8305C), I PTC (BCPAP), and J PTC (TPC-1) cells