Fig. 4

Effect of miR-92a on IC and IR kidneys in mice. The content of serum Cr A and BUN B among groups. The expression of miR-92a C among groups. Each group’s number of autophagosomes D and kidney apoptotic rate E were compared. The kidneys homogeneously absorbed the Cy-3 labeled miR-92a-agomir injected via tail vein (F). In IC and IR mice treated with miR-92a agomir, the representative band G and statistical analysis H of LC3B II/I, Beclin 1, pJNK, JNK, MEK4, and active caspase 3 expression using Western blotting. *P < 0.05. ag 25 nM miR-92a agomir, BUN blood urea nitrogen, Cr creatinine, GAPDH glyceraldehyde phosphate dehydrogenase, IC ischemia and cold preservation, IR ischemia and reperfusion injury, JNK c-Jun NH [2] terminal kinase, LC3B microtubule-associated protein 1 light chain 3B, MEK4 mitogen-activated protein kinase, NC negative control, pJNK phosphorylated JNK