From: The role of noncoding RNAs in metabolic reprogramming of cancer cells
circRNAs | Oncogene/TS | Cancer | Metabolic reprogramming | Mechanism | Refs |
---|---|---|---|---|---|
circMYLK | Oncogene | Lung cancer | Elevating glucose metabolism | Overexpression of GLUT3 by targeting miR-195-5p | [139] |
circMAGI3 | Oncogene | Lung cancer | Elevation of glucose metabolism | Overexpression of HDGF by targeting miR-515-5p | [140] |
circAGFG1 | Oncogene | Lung cancer | Elevation of glucose metabolism | Overexpression of HIF-1α | [141] |
circ-ENO1 | Oncogene | Lung cancer | Elevation of glucose metabolism | Regulating ENO1 expression by targeting miR-22-3p | [142] |
circRAD18 | Oncogene | Papillary thyroid cancer | Elevation of glucose metabolism | Upregulation of PDK1 by targeting miR-516b | [143] |
circRHBDD1 | Oncogene | HCC | Elevation of glucose metabolism | Through an m6A dependent manner | [144] |
circCARM1 | Oncogene | Breast cancer | Elevation of glucose metabolism | Upregulating PFKFB2 by sponging miR-1252-5p | [117] |
piR-Hep1 | Oncogene | HCC | Elevation of glucose metabolism | Activating glycolysis through PI3K/Akt signaling pathway | [145] |
snoRD113-1 | Oncogene | HCC | Elevation of glucose metabolism | Through PI3K/Akt signaling pathway | [146] |
hsa_circ_0018180 (circPARD3) | Oncogenic | Head and neck squamous cell carcinoma | Elevation of glucose metabolism | Through the miR-5194/ENO1 axis | [147] |
circMBOAT2 | Oncogene | ICC | Elevation of lipid metabolism | Stabilizing PTBP1 to facilitate FASN mRNA cytoplasmic export | [148] |
circRIC8B | Oncogene | CLL | Elevation of lipid metabolism | Acting as a sponge of miR-199b-5p and preventing it from decreasing the level of lipoprotein lipase mRNA | [132] |
circ-LDLRAD3 | Oncogene | Lung cancer | Elevation of amino acid metabolism | promoting glutamine metabolism through upregulation of SLC1A5 by targeting miR-137 | [133] |
circ-103809 | Oncogene | NSCLC | Elevation of amino acid metabolism | Upregulating GOT1 and promoting glutamine metabolism by targeting miR-377-3p | [149] |
circ-0003028 | Oncogene | Lung cancer | Elevation of amino acid metabolism | Overexpression of GOT2 by miR-1298-5p | [136] |
circMYH9 | Oncogene | CRC | Elevation of amino acid metabolism | Promotes the expression of serine and glycine synthesis enzymes to facilitate serine and glycine biosynthesis though p53-mediated upregulation of PHGDH | [137] |
circ_0025033 | Oncogene | Ovarian cancer | Elevation of amino acid metabolism | Promotes ovarian cancer cell malignant behaviors and glutamine metabolism via the hsa_miR-370-3p/SLC1A5 axis | [134] |