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Fig. 2 | Cellular & Molecular Biology Letters

Fig. 2

From: PRDX1 negatively regulates bleomycin-induced pulmonary fibrosis via inhibiting the epithelial-mesenchymal transition and lung fibroblast proliferation in vitro and in vivo

Fig. 2

Effect of PRDX1 on BLM-induced EMT and the PI3K/Akt and JNK/Smad signalling pathways in epithelial cells. The BEAS-2B cells were treated with 10 μg/mL BLM. A The morphology of cellular fibrosis was observed under a microscope. B The expression levels of EMT-related proteins. C The expression levels of fibrosis-related proteins. D Secreted TGF-β1 levels as determined using an ELISA kit. E The expression levels of the PI3K/Akt and JNK/Smad signalling pathway-related proteins. F The expression levels of the PI3K/Akt and JNK/Smad signalling pathway-related proteins. G The expression levels of EMT and fibrosis-related proteins. Protein levels were determined by western blot analysis. *, p < 0.05; **, p < 0.01; ***, p < 0.001. PRDX1 peroxiredoxin, BLM bleomycin, EMT epithelial-mesenchymal transition, PI3K phosphoinositide 3-kinase, Akt protein kinase B, JNK c-Jun N-terminal kinase, Smad small of mothers against decapentaplegic, TGF-β1 transforming growth factor β1, ELISA enzyme-linked immunosorbent assay

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Cellular & Molecular Biology Letters

ISSN: 1689-1392

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