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Fig. 5 | Cellular & Molecular Biology Letters

Fig. 5

From: PRDX1 negatively regulates bleomycin-induced pulmonary fibrosis via inhibiting the epithelial-mesenchymal transition and lung fibroblast proliferation in vitro and in vivo

Fig. 5

Effect of PI3K and JNK inhibitors on BLM-induced expression of proteins related to cell cycle and fibrosis in primary lung fibroblasts. FMLF were treated with 10 μg/mL BLM for 72 h. A The expression levels of PI3K/Akt and JNK/Smad signalling pathways-related proteins. B The expression levels of cell cycle-related proteins. C The expression levels of fibrosis-related proteins. Protein expression levels were determined by western blot analysis. *, p < 0.05; **, p < 0.01; ***, P < 0.001. PI3K phosphoinositide 3-kinase, JNK c-Jun N-terminal kinase, BLM bleomycin, FMLF foetal mouse lung fibroblasts, Akt protein kinase B, Smad small of mothers against decapentaplegic

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Cellular & Molecular Biology Letters

ISSN: 1689-1392

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