Fig. 7

Expression of EMT and fibrosis-related proteins after BLM treatment in mice. Lung fibrosis was induced in mice by intratracheal administration of BLM (5 mg/kgBW in 50 μL PBS) for 21 days. A Expression of EMT (N-cadherin, E-cadherin, vimentin, slug), collagen-related (α-SMA, fibronectin, collagen I/III), cell cycle (P16, P21), and PCNA proteins in mouse lung tissues as measured by western blotting. B–M Quantitative analyses of the data presented in panel A. *, p < 0.05; **, p < 0.01; ***, p < 0.001. EMT epithelial-mesenchymal transition, BLM bleomycin, PBS phosphate-buffered saline, α-SMA α-smooth muscle actin, PCNA proliferating cell nuclear antigen