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Fig. 2 | Cellular & Molecular Biology Letters

Fig. 2

From: An Fc-muted bispecific antibody targeting PD-L1 and 4-1BB induces antitumor immune activity in colorectal cancer without systemic toxicity

Fig. 2

HK010 has no cytotoxicity mediated by Fc and no induced cytokine release. HK010 did not mediate ADCC against CHO-K1-h4-1BB cells (A) or PD-L1-expressing HCC1954 cells (B) according to the reporter assay. Anti-4-1BB (IgG1 WT) or anti-PD-L1 avelumab was used as the positive control to elicit ADCC activity. C HK010 did not mediate CDC against CHO-K1-h4-1BB cells or HCC1954 cells. D In vitro evaluation of HK010-induced cytokine release. A cytokine bead array (CBA) was used to evaluate the potential for cytokine release across a gradient of HK010 concentrations (n = 6). The values are presented as the mean ± SD from one representative of three independent experiments. **p < 0.01, ***p < 0.001

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Cellular & Molecular Biology Letters

ISSN: 1689-1392

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