Fig. 3

Acute lung injury was aggravated upon RGS6 knockout. A General observation of the change of lung tissue. B Kaplan–Meier curve showed survival of mice in different groups. C HE staining showed pathological changes in different groups. Scale bar: upper 200 μm, lower 100 μm. D Percentage change of body weight of mice in different groups. E Protein concentration in BALF in different groups. WT PBS, wild type mice given PBS intratracheally and executed at day 3; WT LPS, wild type mice given LPS (3 mg/kg) intratracheally and executed at day 3; RGS6^−/− LPS, RGS6^−/− mice given LPS (3 mg/kg) intratracheally and executed at day 3. Data are shown as mean ± SEM. ^*P < 0.05 vs. WT PBS group; ^***P < 0.001 vs. WT PBS group; ^#P < 0.05 vs. WT LPS group