Table 2 The function of m6A methylation regulators in common types of cancers
From: Role of N6-methyladenosine methylation in glioma: recent insights and future directions
Disease | Regulator | Function | Role in disease | Related targets | References |
|---|---|---|---|---|---|
Lung cancer | METTL3 | Writer | Promote cancer | EGFR, TAZ | [49] |
Endometrial cancer | METTL3/METTL14 | Writer | Inhibit cancer | AKT pathway | [50] |
Pancreatic cancer | ALKBH5 | Eraser | Inhibit cancer | WIF-1 | [51] |
Hepatocellular cancer | YTHDF1 | Reader | Promote cancer | FZD5, WNT/β-catenin pathway | [53] |
YTHDF2 | Reader | Inhibit cancer | IL-11, SERPINE2 | [52] | |
Glioma | METTL3 | Writer | Inhibit cancer | HSP90 | [55] |
METTL3/METTL14 | Writer | Inhibit cancer | ADAM19, EPHA3, KLF4 | [46] | |
WTAP | Writer | Promote cancer | EGFR, AKT, CCL2, CCL3, MMP3, LOXL1, THBS1, HAS1 | [57] | |
FTO | Eraser | Promote cancer | ADAM19, EPHA3, KLF4 |