Role of N6-methyladenosine methylation in glioma: recent insights and future directions

Table 3 M6A methylation-related regulators in GBM

Function	Regulators	Role in GBM	Related targets	References
Writer	METTL3	Promote	↑SOX2, SALL2, SSEA1, POU3F2, OLIG2	[60]
	METTL3	Inhibit	↓EPHA3, ADAM19, KLF4 ↑CDKN2A, BRCA2, TP53I11	[6]
	METTL3	Inhibit	↓PI3K/Akt pathway	[61]
	METTL3	Promote	↑NOTCH3, DLL3, HES1	[63]
	METTL3	Promote	↑VEGF	[65]
	METTL3	Promote	↑MALAT1, NF-κB	[66]
	METTL3	Promote	↑SRSF	[66]
	METTL14	Inhibit	↓EPHA3, ADAM19, KLF4 ↑CDKN2A, BRCA2, TP53I11	[6]
	METTL14	Promote	↓ASS1	[69]
	WTAP	Promote	↑EGFR	[71]
	WTAP	Promote	↑AKT, CCL2, CCL3, MMP3, LOXL1, THBS1, HAS1	[57]
Eraser	ALKBH5	Promote	↑Foxm1	[47]
	ALKBH5	Promote	↑G6PD, PPP	[82]
	ALKBH5	Promote	↑Rad51, XRCC2, BRCA2, EXO1, BRIP1	[84]
	FTO	Promote	↑MYC	[94]
Reader	YTHDF1	Promote	NA
	YTHDF2	Promote	↑MYC, IGFBP3	[98]
	YTHDF2	Promote	↓LXRα, HIVEP2	[99]
	YTHDF2	Promote	↓UBXN1	[100]
	YTHDF2	Promote	↓ASS1	[69]
	IGF2BP1	Promote	↑MAPK	[115]
	IGF2BP2	Promote	↑let-7miRNA	[105]
	IGF2BP2	Promote	↑PI3K/Akt	[107]
	IGF2BP2	Promote	↑DANCR	[110]
	IGF2BP3	Promote	↑PI3K/MAPK	[108]
	IGF2BP3	Promote	↑p65	[112]
	IGF2BP3	Promote	↓E-cadherin	[111]
	IGF2BP3	Promote	↑N-cadherin, vimentin, snail, slug and MMP9	[111]
	hnRNPA2B1	Promote	↑AKT, STAT3 pathway	[120]

ISSN: 1689-1392