Fig. 9

Schematic showing that m6A-modified circRNA3634 promotes the proliferation and differentiation of antler chondrocytes by targeting miR-124486-5—MAPK1. CircRNA3634, originating from COG3 pre-mRNA, undergoes m6A methylation modification facilitated by METTL3 and is subsequently recognized by the reader protein YTHDC1, enabling its export to the cytoplasm. In the cytoplasm, circRNA3634 binds to miR-124486-5, counteracting its suppressive effect on MAPK1. The upregulation of MAPK1 plays a significant role in the promotion of antler chondrocyte proliferation, migration, and differentiation