Fig. 1
From: Molecular mechanism and therapeutic potential of HDAC9 in intervertebral disc degeneration
Decreased expression of HDAC9 in degenerated IVD in patients. A, B GSE56081 dataset (NP tissues from patients with IVDD and normal controls [31]) were analyzed by gene set enrichment analysis (GSEA) based on the Gene Ontology (GO) analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis. C Raincloud plot exhibited DEGs related to protein modification such as ubiquitination, deubiquitination, phosphorylation, dephosphorylation, acylation, and diacylation based on the Gene Ontology resource knowledge base (Raincloud plot was drawn using https://www.chiplot.online/). D Heatmap presented the top three upregulated and downregulated DEGs from C. E UpSet plot displayed the intersections between six deacetylation genes and DEGs from the GSE56081 dataset