Fig. 4
From: The regulatory relationship between transcription factor STAT3 and noncoding RNA
STAT3 can downregulate miRNA expression, forming a STAT3/miRNA/IL-6R positive feedback loop. STAT3 cannot bind to the miR-34a and miR-204 promoters, resulting in inhibition of miRNA expression. At the same time, after IL-6 stimulates CAC cells and EOC cells, the activity of IL-6R, as the direct target of miR-34a and miR-204, is enhanced, and then mediates IL-6 to upregulate the expression of STAT3, forming a positive feedback loop, and promoting the invasion and migration of colorectal cancer cells and the cisplatin resistance of EOC cells