Fig. 1

The dysregulation of miR-4739 and RHBDD2 were associated with the DDP resistance of CC. A, B Parental CC cell lines (HeLa and SiHa) and their corresponding DDP-resistant cell lines (HeLa/DDP and SiHa/DDP) were exposed to 1, 2, 3, 4, 5 μg/ml DDP and the cell viability was determined using CCK-8 assay. C IC50 values of HeLa, HeLa/DDP, SiHa and SiHa/DDP cells were calculated and shown. D The miR-4739 expression levels in HeLa, HeLa/DDP, SiHa and SiHa/DDP cells were determined using quantitative real time PCR. E The protein levels of RHBDD2, P-gP, and MRP1 were detected via western blot analysis in HeLa, HeLa/DDP, SiHa, and SiHa/DDP cells. F MiR-4739 expression in DDP-sensitive and DDP-resistant CC tissues both from patients with CC (n = 35) was determined using quantitative real-time PCR. *p < 0.05, **p < 0.01, ***p < 0.001, compared with HeLa or SiHa via Student’s t-test