Fig. 2

MiR-4739 enhanced the chemosensitivity of CC cells to DDP in vitro. HeLa/DDP and SiHa/DDP cells were transfected with miR-4739 mimics or NC mimics for 48 h and then subjected to treatment with or without 2 μg/ml DDP for 24 h. A The miR-4739 expression levels were determined in the above HeLa/DDP and SiHa/DDP cells. B, C The cell viability of the above HeLa/DDP and SiHa/DDP cells was determined using CCK-8 assay. D IC50 values of the above HeLa/DDP and SiHa/DDP cells were calculated and shown. E, F Colony formation assay. G Cell apoptosis rate was determined by flow cytometry assay. H, I Transwell assay was applied to analyze cell migration ability of the above HeLa/DDP and SiHa/DDP cells. *p < 0.05, **p < 0.01, ***p < 0.001, compared with NC mimics via Student’s t-test