Fig. 6

MiR-4739 overexpression overcome DDP resistance in CC cells by targeting RHBDD2 in vivo. BALB/c nude mice were injected with HeLa/DDP cells (1 × 10⁷) transfected with miR-4739 mimics, NC mimics, and miR-4739 mimics + RHBDD2, respectively (n = 5 per group). After 2 weeks (day 14), the mice were intraperitoneally administered with DDP (20 mg/kg) every week for 4 weeks. A Tumor volume was monitored continuously for 42 days. On day 42, the xenografts were resected (B) and weighed (C). D The representative images of RHBDD2 expression by immunohistochemical stain were shown in xenograft tumor tissues. Scale bar, 50 µm. E The expression of miR-4739 and RHBDD2 was determined by quantitative real time PCR in xenograft tumor tissues. **p < 0.01, ***p < 0.001, compared with NC mimics; ##p < 0.01, ###p < 0.001, compared with miR-4739 mimics