Fig. 6

FFAR4 activation enhances malate–aspartate shuttling in A549 cells. A Overall differences between groups were demonstrated by the using orthogonal partial least-squares discriminant analysis (OPLS-DA). B A random forest approach was used to select the features with the highest contribution to the accuracy of the sample grouping predictions. C Based on the significantly different metabolites, ORA was used to find KEGG pathways that were significantly enriched in metabolites. D Conceptual summary