Fig. 11

Metformin improves cardiac function by alleviating mitochondrial injury and inflammatory response in mice with SCM. A–D Results of echocardiography. LVEF, left ventricular ejection fraction; FS, left ventricular fraction shortening; LVDd, left ventricular diastolic dimension; LVDs, left ventricular systolic dimension. E, F Analysis of the mitochondrial membrane potential in isolated cardiomyocytes loaded with JC-1. G–I Comparison of expression of inflammation factors between different groups (N = 6 mice or eight independent cell samples per group). *p < 0.05, **p < 0.01, ***p < 0.001