Fig. 8

Hypothetical model illustrating the roles of circRNF216 in the inhibition of tumor progression in CRC. CircRNF216 acts as a sponge for miR-576-5p, alleviating miR-576-5p repression on its target ZC3H12C, which in turn downregulated N-cadherin. In addition, circRNF216 could augment the recruitment of CD8⁺ T cells via ZC3H12C, thereby triggering the release of soluble factor, ultimately inhibiting the progression of CRC