Fig. 3

AW1 treatment regulated NF-κB signaling pathway activation in a concentration-dependent manner. A Effects of AW1 on NF-κB signaling pathway activation in deep second-degree burns at day 3 postinjury. B, C Quantification of relative expression of P65, P-P65, Iκb, and P-iκb in wound tissues at day 3. D Inhibitory effects of AW1 on NF-κB signaling pathway activation in deep second-degree burns at day 8 postinjury. E, F Quantification of relative expression of P65, P-P65, Iκb, and P-iκb in wound tissues at day 8. All data are expressed as mean ± SEM from five independent experiments (n = 5); **P < 0.01, ***P < 0.001, and ****P < 0.0001 indicate statistically significant difference compared with vehicle