Fig. 7

AW1 promoted reepithelialization to accelerate diabetic skin wound healing in mice. A Representative images of full-thickness skin wounds in diabetic mice under PBS, rh-bFGF (100 ng/mL), or AW1 (1, 10, and 100 nM) treatment on days 0, 4, 8, 12, and 18. B–E Quantification of wound repair rate on days 4, 8, 12, and 18. F H&E staining of full-thickness skin wounds in diabetic mice on days 8, 12, and 18. Yellow dotted lines represent areas of neoepidermis; Es, eschar; NE, neoepidermis; GT, regenerated granulation tissue; scale bar 200 μm. G–L Quantification of neoepidermis and new granulation tissue thickness on days 8, 12, and 18. All data are expressed as mean ± SEM from six mice (n = 6); ^#P < 0.05, ^##P < 0.01, and ^###P < 0.001 indicate statistically significant difference compared with normal control; *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001 indicate statistically significant difference compared with diabetic control