Fig. 8

AW1 promoted angiogenesis to accelerate diabetic skin wound healing. A Images of immunofluorescence staining of VEGF, α-SMA, and CD31 in diabetic skin wounds on day 18. Red fluorescence for VEGF, α-SMA, and CD31, and DAPI blue fluorescence for nuclei; scale bar 50 µm. B Quantification of VEGF expression. C Quantification of α-SMA expression. D Quantification of CD31 expression. All data are expressed as mean ± SEM from six mice (n = 6); ^###P < 0.001 and ^####P < 0.0001 indicate statistically significant difference compared with normal control; **P < 0.01, ***P < 0.001, and ****P < 0.0001 indicate statistically significant difference compared with diabetic control