Fig. 6
From: IGF2BP3 prevent HMGB1 mRNA decay in bladder cancer and development
IGF2BP3 promotes EMT, migration, invasion, and metastasis of bladder cancer cells. A–C GSEA analysis reveals a positive correlation between IGF2BP3 mRNA levels and HALLMARKs of “ANGIOGENESIS” and “EPITHELIAL MESENCHYMAL TRANSITION” signature in TCGA BLCA, GSE31684 and E-MTAB-4321 datasets. D Western blot analysis of E-cadherin, N-cadherin, Vimentin, Snail, Slug, MMP9, and KLF4 protein levels after IGF2BP3 overexpression in RT112/84 and IGF2BP3 knockdown in BFTC905 cells. E–I Scatterplot exhibiting the mRNA expression correlation between IGF2BP3 and CDH2/VIM/SNAI1/SNAI2/MMP9 in the TCGA BLCA dataset. J, K Assessment of the effect of IGF2BP3 expression on cell invasion in RT112/84 and BFTC905 cells using a transwell assay. L, M Evaluation of the effect of IGF2BP3 expression on cell migration in RT112/84 and BFTC905 cells through a wound-healing assay