Fig. 8
From: IGF2BP3 prevent HMGB1 mRNA decay in bladder cancer and development
HMGB1 inhibitor glycyrrhizin reverses the cancer-promoting effect induced by IGF2BP3 overexpression. A Western blot analysis of protein levels in HMGB1, Cyclin B, Cyclin E, E-cadherin, N-cadherin, Vimentin, Snail, Slug, MMP9 in IGF2BP3-overexpression RT112/84 and BFTC905 cells treated with increasing concentrations of HMGB1 inhibitor glycyrrhizin (GA) for 24 h. B–D The effect of glycyrrhizin on cell migration and invasion of IGF2BP3-overexpression RT112/84 and BFTC905 cells was evaluated by wound-healing assay and transwell assay, respectively. E Schematic representation of the study