Fig. 4

Downregulation of circ-SLC16A1 suppressed NSCLC cell migration and promoted cell apoptosis. A and B Transwell detection showing the migration of both A549 and H1833 cells after transfection with NC or si-circ-SLC16A1. Data presented as mean ± SD. *P < 0.05, **P < 0.01 versus NC. C and D Wound healing detection show the migration ability of A549. Data presented as mean ± SD. *P < 0.05 versus NC. E and F The apoptosis of A549 and HCC1833 cells was assessed using flow cytometry with annexin V-FITC staining. Data presented as mean ± SD. ***P < 0.001 versus NC. G–J Western blot detection showing the expression of apoptosis-related protein Bax and Bcl-2. Data presented as mean ± SD. *P < 0.05, ***P < 0.001 versus NC