Table 1 Hallmark gene sets from MSigDB based on GSEA with normalized counts of all expressed genes found by RNA-Seq, showing significantly enriched pathways after miR-101-3p reexpression in MEL-JUSO compared with siCtrl
From: Loss of miR-101-3p in melanoma stabilizes genomic integrity, leading to cell death prevention
POS | NAME | SIZE | NES | FDR | POS | NAME | SIZE | NES | FDR |
|---|---|---|---|---|---|---|---|---|---|
1 | EPITHELIAL MESENCHYMAL TRANSITION | 182 | 2.4 | < 1.0 × 10−4 | 11 | INTERFERON GAMMA RESPONSE | 178 | 1.52 | 2.0 × 10−2 |
2 | TNFA SIGNALING VIA NFKB | 190 | 2.1 | < 1.0 × 10−4 | 12 | KRAS SIGNALING UP | 162 | 1.49 | 2.4 × 10−2 |
3 | INTERFERON ALPHA RESPONSE | 90 | 1.9 | 6.1 × 10−4 | 13 | P53 PATHWAY | 181 | 1.48 | 2.5 × 10−2 |
4 | IL6 JAK STAT3 SIGNALING | 68 | 1.9 | 1.2 × 10−3 | 14 | COAGULATION | 111 | 1.47 | 2.7 × 10−2 |
5 | APOPTOSIS | 146 | 1.7 | 6.6 × 10−3 | 15 | INFLAMMATORY RESPONSE | 167 | 1.45 | 3.0 × 10−2 |
6 | UNFOLDED PROTEIN RESPONSE | 107 | 1.7 | 9.4 × 10−3 | 16 | TGF BETA SIGNALING | 53 | 1.33 | 8.7 × 10−2 |
7 | HYPOXIA | 182 | 1.6 | 9.5 × 10−3 | 17 | ALLOGRAFT REJECTION | 148 | 1.30 | 9.9 × 10−2 |
8 | DNA REPAIR | 147 | 1.6 | 1.8 × 10−2 | 18 | COMPLEMENT | 173 | 1.30 | 9.9 × 10−2 |
9 | UV RESPONSE DN | 135 | 1.5 | 2.0 × 10−2 | 19 | PROTEIN SECRETION | 94 | 1.29 | 9.8 × 10−2 |
10 | ANGIOGENESIS | 27 | 1.5 | 1.8 × 10−2 | 20 | CHOLESTEROL HOMEOSTASIS | 73 | 1.28 | 1.0 × 10−1 |