Table 1 The functional roles of CELF1 in cancer
From: Curriculum vitae of CUG binding protein 1 (CELF1) in homeostasis and diseases: a systematic review
Genes | Pathways/binding site | Target genes | Functions | Refs. |
|---|---|---|---|---|
CELF1 | 3 ‘UTR GREs | DEK | Stabilize DEKmRNA and amplify carcinogenic signaling | [64] |
Untranslated and overexpressed regions | CDKN1B | Inhibit the expression of CDKN1B and promote the proliferation of cancer cells | [69] | |
ERBB2/MAPK/P13K | AKT/ERK | Promote the proliferation of cancer cells | ||
mRNA 3 ‘UTR | ETS2 | Promote the proliferation、metastasis and invasion of cancer cells | [73] | |
mRNA 3 ‘UTR | BAX/BAD/JunD | Inhibit the expression of BAX/BAD/JunD and promote the proliferation of cancer cells | [76] | |
C/EBPa | C/EBPa | Inhibit the expression of C/EBPa and promote the proliferation of cancer cells | ||
INSR shear | IR-A | Promote IR-A expression, and influences carcinogenic signaling through the insulin-signaling pathway of breast cancer | [87] | |
MiR-330-3p | mRNA 3 ‘UTR | CELF1 | Down-regulating the expression of CELF1 inhibited the proliferation and migration of glioma cells | [68] |
BACE1-AS | miR-377-3p | miR-377-p/CELF1 axis | Promoting the invasion and metastasis of liver cancer cells | [92] |