Fig. 7
ASK1 inhibition alleviated hepatic GSTM1 knockdown-aggravated ALD. A Functional proteins interacting with GSTM1 predicted by STRING database. B The phosphorylated and total protein abundance of ASK1, JNK, and p38 in mice liver. C Exogenous IP assays were performed in mouse AML-12 hepatocytes transfected with HA-GSMT1 and Flag-ASK1. D, E Plasma ALT and AST activities. F H&E staining. G Liver TG content. H Oil red O staining. I Liver lipid metabolism genes expression. AF alcohol-fed. B, D–I (n = 6); C (n = 3)