Fig. 6

Effect of mifepristone on the activity of promoter containing PPAR response elements and its dependence on the co-expression of PPARγ2 and RXRα in COS7 cells. A The concentration-dependent effects of mifepristone on the activity of promoter containing three copies of PPAR response element in COS7 cells, which were co-transfected with PPARγ2 and RXRα expression vectors. B Summary of the effects of mifepristone (1 and 10 µM) and pioglitazone (1 µM) on the promoter activity of PPAR response element with and without the co-expression of PPARγ2 and RXRα or co-treatment with the PPARγ2 antagonist, T00709007 (10 µM), as indicated. The data represent the mean ± S.E.M. of triplicate measurements of one set of experiments. Similar results were obtained with an additional two sets of experiments