Table 1 Role of various lncRNAs in breast cancer
From: Role of ferroptosis and ferroptosis-related long non'coding RNA in breast cancer
LncRNA | Regulation | Work | References |
|---|---|---|---|
HOTAIR | – | Potential metastatic, drug-resistant and prognostic regulators of BC; highly predictive of metastatic disease progression and overall survival | |
miR-206 | Enhances BC cell proliferation | [129] | |
Chondroitin sulfate | Enhances BC cell invasion | [130] | |
miR-203/CAV1 axis | Influences BC cell migration, proliferation and invasion | [104] | |
miR-20a-5p/HMGA2 axis | Influences BC cell apoptosis, growth, migration and invasion | [131] | |
miR-129-5p/FZD7 axis | Promotes BC | [125] | |
UCA1 | miR-375 | Inhibits BC progression | [132] |
RP11-19E11 | E2F1 | Proliferation and survival of basal BC | [133] |
LINC00963 | miR-324-3p/ ACK1 | Promotes tumourigenesis and radiation resistance in BC | [134] |
LINC00899 | miR-425 | Inhibits BC cell migration, proliferation and invasion | [135] |
LINC01787 | niR-125b | Promotes BC cell growth, proliferation and migration of BC xenografts | [136] |
NKILA | IκB | Inhibits BC metastasis | [137] |
Gas5 | – | Sensitizes BC cells to ionising radiation by inhibiting DNA repair | [138] |
NORAD | PUM1/Eif2 axis | Inhibits BC progression | [139] |
TGFβ | High expression is indicative of poor prognosis | [140] | |
YAP pathway | Inhibits BC metastasis | [141] | |
BCRT1 | miR-1303/PTBP3 axis | Promotes BC progression | [142] |
SEMA3B-AS1 | miR-3940/KLLN axis | Inhibits BC progression | [143] |
NR2F1-AS1 | IGF-1/IGF-1R/ERK pathway | Promotes angiogenesis in BC | [144] |
BC069792 | KCNQ4 | Inhibits tumour progression in BC | [145] |
SNHG1 | macrophage M2-like polarization | Promotes BC growth and metastasis | [146] |
GHET1 | EMT | Promotes BC cell proliferation, invasion and migration | [111] |
PRNCR1 | microRNA-377/CCND2/MEK/MAPK axis | Promotes BC proliferation and inhibit apoptosis | [147] |
NEAT1 | miR-133b | Promotes migration and invasion of BC cells | [148] |
NEF | – | Downregulated expression is suggestive of poor prognosis | [149] |
TPA | TGFβ | Promotes BC invasion and metastasis | [150] |
ERINA | E2F1/RB1 pathway | Inhibits cell-cycle progression and tumour cell proliferation | [151] |
LCPAT1 | MFAP2 | Promotes BC progression | [152] |
PlncRNA-1 | TGFβ1, PHGDH | Inhibits the growth of BC | [153] |
ITGB2-AS1 | ITGB2 | Promotes BC migration and invasion | [154] |
RP1-5O6.5 | KLF5 | Promotes growth and metastasis of BC | [155] |
LSINCT5 | – | Promotes BC cell proliferation | [105] |
LncRNA-CDC6 | microRNA-251 | Promotes BC progression and function as ceRNA | [156] |
MALAT1 | miR-497-5p/SHOC2 axis | Regulates the paclitaxel resistance of BC | [157] |
– | Overexpression inhibits BC metastasis in transgenic, xenograft and homologous models | [158] | |
Uc003xsl.1 | NFκB/IL8 axis | Promotes progression of TNBC, growth and metastasis | [159] |
CARMN | miR143-3p | Promotes prognosis and chemosensitivity of TNBC | |
BREA2 | Notch signalling | Drivers of metastasis in BC | [162] |
DIO3OS | PTBP1, LDHA | Correlated with a worse prognosis in BC patients on AI therapies | [163] |
KB-1980E6.3 | lncRNA KB-1980E6.3/IGF2BP1/c-Myc axis | Maintain the stemness of BC stem cells | [164] |
BORG | TRIM28, BORG | Drives BC metastasis and disease recurrence; elicits the metastatic outgrowth of latent BC cells | [165] |
EPB41L4A-AS1 | – | Regulates cell metastasis, proliferation and apoptosis in BC | [166] |
FOXD3-AS1 | miR-127-3p | Affects BC cell proliferation, migration, invasion and growth | [167] |
LGALS8-AS1 | miR-125b-5p/SOX12 | Promotes BC metastasis | [168] |
CASC15 | miR-654-5p/MEF2D axis | Regulates BC cell stemness | [169] |
GHET1 | – | Knockdown suppresses BC activity | [170] |
DUXAP8 | PI3K/AKT/mTOR pathway, EZH2-E-cadherin/ RHOB axis | Promotes radiation resistance in BC | [171] |
RP11-214F16.8 | SENP3 | Drives BC tumourigenesis | [172] |
MIR17HG | miR-454-3p | Suppresses BC cell proliferation and migration | [173] |
EGOT | Hedgehog pathway | Decreases BC cell viability and migration | [174] |
SNHG6 | miR-26a/VASP axis | Silencing suppresses proliferation and invasion of BC cells | [175] |
SNHG8 | miR-634/ZBTB20 axis | Serves as an oncogene in BC | [176] |
PVT1 | miR-145-5p | Influences glycolysis in BC cells | [177] |
APOC1P1-3 | miRNA-188-3p | Promotes metastasis in BC | [178] |
FGD5-AS1 | has-miR-195-5p/NUAK2 axis | Promotes BC progression | [179] |
FBXL19-AS1 | miR-718 | Promotes proliferation and invasion of BC cells | [180] |
PTCSC3 | lncRNA H19 | Inhibits TNBC cell proliferation | [181] |