Fig. 6

Inhibition of the PI3K/AKT/mTOR signaling pathway by (+)-ABX in NSCLC cells. A Impact of different concentrations of (+)-ABX treatment on the expression of PI3K/AKT/mTOR signaling pathway-related proteins in cells determined by western blotting. B Quantification of the data presented in (A). C Changes in the expression of PI3K/AKT/mTOR signaling pathway-related proteins upon intervention with LY294002 after treatment with (+)-ABX assessed by western blotting. D Quantification of the data presented in (C). E Alterations in the expression of apoptosis and autophagy-related proteins upon LY294002 intervention after treatment with (+)-ABX measured by western blotting. F Quantification of the data presented in (E). G Evaluation of the impact of LY294002 pretreatment on cell viability upon (+)-ABX treatment using the CCK-8 assay. Values are expressed as means ± SD. * or ^△P < 0.05, ** or ^△△P < 0.01, and ***P < 0.001, compared with the control. Data were collected from a minimum of three independent experiments