Fig. 8

Impact of (+)-ABX on xenograft model in nude mice. A Ex vivo tumor imaging. B The tumor weight (n = 6). C Tumor growth curve plotted based on tumor volume measurements (n = 6). D Curve depicting changes in mouse body weight (n = 6). E Representative pathological sections of major organs and tumor tissues stained with H&E (n = 6). Scale bar, 50 μm. F IHC staining of Ki67, AKT, BAX, cleaved-caspase 3, cleaved-caspase 9, LC3A, and Beclin1 expression in tumor tissues. Scale bar, 100 and 50 μm. G Quantification of integrated optical density of IHC staining in (E). n = 3 (Additional file 1: Table S2). Data were presented as means ± SD. *P < 0.05, **P < 0.01, and ***P < 0.001 compared with the control. Information was collected from a minimum of three independent experiments