The breakdown of bilayer lipid membranes by dendrimers
© University of Wrocław 2006
Received: 3 January 2006
Accepted: 16 March 2006
Published: 01 June 2006
The BLM-system for studying the electrophysical properties of bilayer lipid membranes (BLM) was applied to investigate interactions between polyamidoamine (PAMAM) dendrimers and lipid bilayers. The cationic PAMAM G5 dendrimer effectively disrupted planar phosphatidylcholine membranes, while the hydroxyl PAMAM-OH G5 and carboxyl PAMAM G4.5 dendrimers had no significant effect on them.