Open Access

A comparison of the in vitro antimicrobial activity of liposomes containing meropenem and gentamicin

  • Zuzanna Drulis-Kawa1, 3Email author,
  • Jerzy Gubernator2, 4,
  • Agata Dorotkiewicz-Jach1,
  • Włodzimierz Doroszkiewicz1 and
  • Arkadiusz Kozubek2
Cellular & Molecular Biology LettersAn International Journal11:360

DOI: 10.2478/s11658-006-0030-6

Received: 15 March 2006

Accepted: 19 May 2006

Abstract

The antimicrobial activity of eight cationic, two neutral and three anionic liposome compositions containing meropenem and gentamicin was tested in vitro in broth and serum medium. The cationic formulations showed better antibacterial efficacy against both Gram-positive and Gram-negative bacteria than the anionic and neutral ones, regardless of the encapsulated drug. The most effective formulations were the cationic PC/DOPE/DOTAP 3:4:3 and PC/Chol/DOTAP 3:4:3, as the MICs with meropenem were 2 to 4 times lower than those of the free drug.

Key words

Liposomes Meropenem Gentamicin Bacteria

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