Open Access

N-terminal brain natriuretic propeptide levels correlate with procalcitonin and C-reactive protein levels in septic patients

  • Mariusz Piechota1,
  • Maciej Banach2Email author,
  • Robert Irzmański3,
  • Małgorzata Misztal4,
  • Jacek Rysz5,
  • Marcin Barylski3,
  • Magdalena Piechota-Urbańska6,
  • Jan Kowalski3 and
  • Lucjan Pawlicki3
Cellular & Molecular Biology LettersAn International Journal200612:62

DOI: 10.2478/s11658-006-0062-y

Received: 11 May 2006

Published: 6 December 2006

Abstract

The aim of this study was to find the relationship between N-terminal brain natriuretic propeptide (NT-proBNP), procalcitonin (PCT) and C-reactive protein (CRP) plasma concentrations in septic patients. This was a prospective study, performed at Medical University Hospital No. 5 in łódź. Twenty patients with sepsis and severe sepsis were included in the study. N-terminal brain natriuretic propeptide, procalcitonin and C-reactive protein concentrations, and survival were evaluated. In the whole studied group (128 measurements), the mean NT-proBNP, procalcitonin and C-reactive protein concentrations were, respectively: 140.80±84.65 pg/ml, 22.32±97.41 ng/ml, 128.51±79.05 mg/l. The correlations for the NT-proBNP level and procalcitonin and C-reactive protein levels were 0.3273 (p<0.001) and 0.4134 (p<0.001), respectively. NT-proBNP levels correlate with PCT and CRP levels in septic patients. In the survivor subgroup, the mean NT-proBNP plasma concentrations were significantly lower than in the non-survivor subgroup.

Key words

N-terminal brain natriuretic propeptide Procalcitonin C-reactive protein Sepsis Severe sepsis

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