Open Access

Natriuretic peptides in cardiovascular diseases

Cellular & Molecular Biology LettersAn International Journal200813:46

DOI: 10.2478/s11658-007-0046-6

Received: 18 January 2007

Accepted: 8 May 2007

Published: 10 April 2008


The natriuretic peptide family comprises atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), C-type natriuretic peptide (CNP), dendroaspis natriuretic peptide (DNP), and urodilatin. The activities of natriuretic peptides and endothelins are strictly associated with each other. ANP and BNP inhibit endothelin-1 (ET-1) production. ET-1 stimulates natriuretic peptide synthesis. All natriuretic peptides are synthesized from polypeptide precursors. Changes in natriuretic peptides and endothelin release were observed in many cardiovascular diseases: e.g. chronic heart failure, left ventricular dysfunction and coronary artery disease.

Key words

Atrial natriuretic peptide Brain natriuretic peptide C-type natriuretic peptide Dendroaspis natriuretic peptide Urodilatin Endothelin-1