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  • Review Article
  • Published:

Natriuretic peptides in cardiovascular diseases

Abstract

The natriuretic peptide family comprises atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), C-type natriuretic peptide (CNP), dendroaspis natriuretic peptide (DNP), and urodilatin. The activities of natriuretic peptides and endothelins are strictly associated with each other. ANP and BNP inhibit endothelin-1 (ET-1) production. ET-1 stimulates natriuretic peptide synthesis. All natriuretic peptides are synthesized from polypeptide precursors. Changes in natriuretic peptides and endothelin release were observed in many cardiovascular diseases: e.g. chronic heart failure, left ventricular dysfunction and coronary artery disease.

Abbreviations

ACTH:

adrenocorticotropic hormone

ANP:

atrial natriuretic peptide

AVP:

arginine vasopressin

BNP:

brain natriuretic peptide

CHF:

chronic heart failure

CNP:

C-type natriuretic peptide

cGMP:

cyclic guanosine monophosphate

DNP:

dendroaspis natriuretic peptide

ET:

endothelin

FGF:

fibroblast growth factor

NO:

nitric oxide

NYHA:

New York Heart Association

PAI:

plasminogen activator inhibitor

PGDF:

platelet derived growth factor

TGF:

transforming growth factor

TIMP:

tissue inhibitor of matrix metalloproteinase

TNF:

tumor necrosis factor

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Piechota, M., Banach, M., Jacoń, A. et al. Natriuretic peptides in cardiovascular diseases. Cell Mol Biol Lett 13, 155–181 (2008). https://doi.org/10.2478/s11658-007-0046-6

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