Open Access

Kinetic models for stochastically modified ionic channels

Cellular & Molecular Biology LettersAn International Journal200813:10

DOI: 10.2478/s11658-008-0010-0

Received: 26 September 2007

Accepted: 23 January 2008

Published: 2 April 2008

Abstract

Ionic channels form pores in biomembranes. These pores are large macromolecular structures. Due to thermal fluctuations of countless degrees-of-freedom of the biomembrane material, the actual form of the pores is permanently subject to modification. Furthermore, the arrival of an ion at the binding site can change this form by repolarizing the surrounding aminoacids. In any case the variations of the pore structure are stochastic. In this paper, we discuss the effect of such modifications on the channel conductivity. Applying a simple kinetic description, we show that stochastic variations in channel properties can significantly alter the ionic current, even leading to its substantial increase or decrease for the specific matching of some time-scales of the system.

Key words

Ionic channel Fluctuations Kinetic model Resonant activation

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