Open Access

The influence of LTS-4, a saponoside from Lysimachia thyrsiflora L., on human skin fibroblasts and human melanoma cells

  • Agnieszka Galanty1Email author,
  • Marta Michalik2,
  • Łukasz Sędek2 and
  • Irma Podolak1
Cellular & Molecular Biology LettersAn International Journal200813:13

DOI: 10.2478/s11658-008-0013-x

Received: 25 October 2007

Accepted: 29 January 2008

Published: 13 June 2008

Abstract

We investigated the effect of a triterpene saponoside from Lysimachia thyrsiflora L. upon the viability, proliferation, morphology and cell motility of human melanoma HTB-140 cells and human skin fibroblasts (HSFs). The compound, denoted LTS-4, decreased the viability and rate of cell growth of both cell types in a time-and dose-dependent manner, and proved cytotoxic against cancer cells at significantly lower concentrations than for fibroblasts. LTS-4 also affected the morphology of the examined cells, causing vacuolisation and actin cytoskeleton disintegration, and had an inhibitory effect on the tumour cell motility.

Key words

Triterpene saponoside Cytotoxicity Lysimachia thyrsiflora L. Melanoma Fibroblasts

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