- Mini Review
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The interaction between L1-type proteins and ankyrins - a master switch for L1-type CAM function
Cellular & Molecular Biology Letters volume 14, pages 57–69 (2009)
Abstract
L1-type cell adhesion molecules (CAMs) are important mediators of neural differentiation, including axonal outgrowth and pathfinding and also of synapse formation and maintenance. In addition, their interactions with cytoskeletal components are highly conserved and regulated. How these different aspects of CAM functionality relate to each other is not well understood. Based on results from our and other laboratories we propose that ankyrin-binding to L1-type CAMs provides a master switch. The interaction with ankyrins directs L1-type adhesive proteins into different functional contexts, either ankyrin-independent functions, such as neurite outgrowth and axonal pathfinding or into ankyrin-dependent functions, such as L1’s role at axon initial segments (AIS), paranodal regions, synapses and in dendrites.
Abbreviations
- AIS:
-
axon initial segments
- CAM:
-
cell adhesion molecule
- EGFR:
-
epidermal growth factor receptor
- FGFR:
-
fibroblast growth factor receptor
- GF:
-
giant fiber
- GPI:
-
glycosyl phosphoinositol
- NMJ:
-
neuromuscular junction
- RTK:
-
receptor tyrosine kinase
- SAP:
-
synapse-associated proteins
- TTMn:
-
tergotrochanteral motorneuron
- VUM:
-
ventral unpaired median
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The content of this Mini review was first presented in a shortened form at the 12th Mejbaum-Katzenellenbogen Seminar “Membrane Skeleton. Recent Advances and Future Research Directions”, June 15–18, 2008, Zakopane, Poland
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Hortsch, M., Nagaraj, K. & Godenschwege, T.A. The interaction between L1-type proteins and ankyrins - a master switch for L1-type CAM function. Cell Mol Biol Lett 14, 57–69 (2009). https://doi.org/10.2478/s11658-008-0035-4
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DOI: https://doi.org/10.2478/s11658-008-0035-4