Overexpression of human osteopontin increases cell proliferation and migration in human embryo kidney-293 cells
© © Versita Warsaw and Springer-Verlag Berlin Heidelberg 2009
Received: 3 March 2009
Accepted: 19 June 2009
Published: 27 June 2009
Malignant tumors are characterized by dysregulated cell growth and the metastasis of secondary tumors. Numerous studies have documented that osteopontin (OPN) plays a key role in regulating tumor progression and metastasis. Here, we show that the overexpression of OPN in human embryo kidney-293 cells significantly increases both the level of cell proliferation, by provoking the G1/S transition, and the level of cell migration in vitro. These findings suggest that augmented OPN contributes to cell growth and motility. Inhibiting OPN or the pathway it stimulates may therefore represent a novel approach for the treatment of primary tumors and associated metastases.