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The antioxidant properties of carnitine in vitro

Cellular & Molecular Biology Letters volume 15, pages 90–97 (2010)Cite this article

Abstract

Many of the effects of carnitine are ascribed to its antioxidant properties. The aim of this study was to evaluate the antioxidant properties of carnitine in vitro. Carnitine was found to decolorize ABTS•+, and to protect fluorescein against bleaching induced by AAPH-derived peroxyl radicals and peroxynitrite, thiol groups against oxidation induced by hydrogen peroxide, peroxyl radicals, hypochlorite and peroxynitrite, and erythrocytes against hemolysis induced by peroxyl radicals and hypochlorite. These results show that carnitine has a direct antioxidant action against physiologically relevant oxidants.

Abbreviations

AAPH:

2,2′-azobis(2-amidinopropane) dihydrochloride

ABTS:

2,2′-azino-bis(3-ethylbenzthiazoline-6-sulfonate)

DTNB:

5,5′-dithio-bis(2-nitrobenzoic acid)

PBS:

phosphate-buffered saline

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Authors and Affiliations

  1. Department of Biochemistry and Cell Biology, University of Rzeszów, Pigonia 6, 35-959, Rzeszów, Poland

    Katarzyna Solarska, Anna Lewińska & Grzegorz Bartosz

  2. Clinic of High-Risk Pregnancy, Medical University of Łódź, Wileńska 37, 94-029, Łódź, Poland

    Agata Karowicz-Bilińska

  3. Department of Molecular Biophysics, University of Łódź, Banacha 12/16, 90-237, Łódź, Poland

    Grzegorz Bartosz

Authors
  1. Katarzyna Solarska
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  2. Anna Lewińska
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  3. Agata Karowicz-Bilińska
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  4. Grzegorz Bartosz
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Correspondence to Grzegorz Bartosz.

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Solarska, K., Lewińska, A., Karowicz-Bilińska, A. et al. The antioxidant properties of carnitine in vitro . Cell Mol Biol Lett 15, 90–97 (2010). https://doi.org/10.2478/s11658-009-0036-y

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  • DOI: https://doi.org/10.2478/s11658-009-0036-y

Key words

Cellular & Molecular Biology Letters

ISSN: 1689-1392

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